Title : The ts13 mutation in the TAF(II)250 subunit (CCG1) of TFIID directly affects transcription of D-type cyclin genes in cells arrested in G1 at the nonpermissive temperature.

Pub. Date : 1997 Jun

PMID : 9154827






1 Functional Relationships(s)
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1 In in vitro assays, upstream sequence-dependent transcription from the human cyclin D1 promoter was significantly reduced in ts13 nuclear extracts preincubated at 30 degrees C but not in similarly treated BHK nuclear extracts, and transcription in the ts13 extract was restored by addition of an affinity-purified human TFIID. (2R)-2-benzyl-5-hydroxy-4-oxopentanoic acid cyclin D1 Homo sapiens