Title : Induction of O6-alkylguanine-DNA-alkyltransferase in the hepatocytes of rats following treatment with 2-acetylaminofluorene.

Pub. Date : 1997 Apr

PMID : 9150437






6 Functional Relationships(s)
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1 Induction of O6-alkylguanine-DNA-alkyltransferase in the hepatocytes of rats following treatment with 2-acetylaminofluorene. 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 Molecular and immunohistological techniques have been used to study the induction in rat liver of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase), following an acute dose (60 mg/kg) of the hepatocarcinogen, 2-acetylaminofluorene (2-AAF). 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus
3 Molecular and immunohistological techniques have been used to study the induction in rat liver of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase), following an acute dose (60 mg/kg) of the hepatocarcinogen, 2-acetylaminofluorene (2-AAF). 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus
4 Molecular and immunohistological techniques have been used to study the induction in rat liver of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase), following an acute dose (60 mg/kg) of the hepatocarcinogen, 2-acetylaminofluorene (2-AAF). 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus
5 Molecular and immunohistological techniques have been used to study the induction in rat liver of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase), following an acute dose (60 mg/kg) of the hepatocarcinogen, 2-acetylaminofluorene (2-AAF). 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus
6 Thus, ATase induction in response to 2-AAF treatment was an hepatocyte-specific response and not confined to any particular region of the liver lobule. 2-Acetylaminofluorene O-6-methylguanine-DNA methyltransferase Rattus norvegicus