Title : 5-Aminolevulinate synthase expression and hemoglobin synthesis in a human myelogenous leukemia cell line.

Pub. Date : 1997 Mar

PMID : 9133617






3 Functional Relationships(s)
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1 We examined the effect of hemin, TGF-beta1 and cytosine arabinoside (Ara-C) on the levels of mRNAs for the erythroid-specific 5-aminolevulinate synthase (ALAS-E) and gamma-globin in various human myelogenous leukemia cell lines. Cytarabine hemoglobin subunit gamma 1 Homo sapiens
2 We examined the effect of hemin, TGF-beta1 and cytosine arabinoside (Ara-C) on the levels of mRNAs for the erythroid-specific 5-aminolevulinate synthase (ALAS-E) and gamma-globin in various human myelogenous leukemia cell lines. Cytarabine hemoglobin subunit gamma 1 Homo sapiens
3 In contrast, gamma-globin mRNA was already markedly expressed prior to treatment in 4 out of 9 cell lines examined, including YN-1, and the level increased only marginally after treatment with hemin. Hemin hemoglobin subunit gamma 1 Homo sapiens