Pub. Date : 1997 Mar
PMID : 9125666
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acute and chronic in vivo inhibition of angiotensin-converting enzyme by perindopril in the endothelium and adventitia of large arteries and organs of the rabbit. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 2 | In this study, we evaluated the acute and chronic in vivo inhibition of ACE by perindopril in both the endothelium and adventitia of large blood vessels including the aorta, carotid, and femoral arteries, heart, lung, and kidney by using in vitro autoradiography with [(125)I]351A as a ligand. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 3 | After short-term (0.1, 0.3, and 1 mg/kg) or long-term oral administration (0.3 mg/kg), perindopril significantly inhibited plasma ACE (p < 0.001), the plasma angiotensin II (Ang II)/Ang I ratio (p < 0.01), and decreased mean arterial pressure (p < 0.001) in a dose-related manner. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 4 | In the aorta, carotid, and femoral arteries, free ACE was inhibited to a similar extent in both the endothelium and adventitia by perindopril, in a dose-dependent manner, whereas total ACE in both layers of these vessels was unaltered. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 5 | Similar short- and long-term ACE inhibition by perindopril was observed in the lung and heart, with somewhat greater inhibition of kidney and plasma ACE. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |
| 6 | These results demonstrate that perindopril readily penetrates the vascular wall after short- or long-term oral administration, and in a dose-dependent manner, potently inhibits both endothelial and advential vascular ACE to a comparable degree. | Perindopril | angiotensin-converting enzyme | Oryctolagus cuniculus |