Pub. Date : 1997 May 2
PMID : 9115297
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Two tyrosine phosphoproteins in phorbol ester-sensitive EL4 (S-EL4) mouse thymoma cells have been identified as the p120 c-Cbl protooncogene product and the p85 subunit of phosphatidylinositol 3-kinase. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |
| 2 | Tyrosine phosphorylation of p120 and p85 increased rapidly after phorbol ester stimulation. | Tyrosine | extracellular matrix protein 1 | Mus musculus |
| 3 | Tyrosine phosphorylation of p120 and p85 increased rapidly after phorbol ester stimulation. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |
| 4 | Co-immunoprecipitation experiments revealed complexes of c-Cbl with p85, and of p85 with the tyrosine kinase Lck in phorbol ester-stimulated S-EL4 but not in unstimulated S-EL4 or in R-EL4 cells. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |
| 5 | Co-immunoprecipitation experiments revealed complexes of c-Cbl with p85, and of p85 with the tyrosine kinase Lck in phorbol ester-stimulated S-EL4 but not in unstimulated S-EL4 or in R-EL4 cells. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |
| 6 | In vitro kinase assays revealed phosphorylation of p85 by Lck only in phorbol ester-stimulated S-EL4 cells. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |
| 7 | Greatly decreased tyrosine phosphorylation of c-Cbl and p85 in the complexes may contribute to the failure of R-EL4 cells to respond to phorbol ester. | Tyrosine | extracellular matrix protein 1 | Mus musculus |
| 8 | Greatly decreased tyrosine phosphorylation of c-Cbl and p85 in the complexes may contribute to the failure of R-EL4 cells to respond to phorbol ester. | Phorbol Esters | extracellular matrix protein 1 | Mus musculus |