Title : In functional experiments, risperidone is selective, not for the B, but for the A subtype of alpha 1-adrenoceptors.

Pub. Date : 1996 Jan 4

PMID : 8925876






1 Functional Relationships(s)
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1 The potency of the antipsychotic drug, risperidone, to antagonize alpha 1A-adrenoceptor-mediated contraction in rat vas deferens and vasoconstriction in rat perfused kidney, and alpha 1B-adrenoceptor-mediated contractions in spleen from guinea-pig and mouse was evaluated and compared to that of alpha 1-adrenoceptor subtype-discriminating antagonists. Risperidone adrenoceptor alpha 1A Rattus norvegicus