Title : Induction of cytochrome P450 2A6 expression in humans by the carcinogenic parasite infection, opisthorchiasis viverrini.

Pub. Date : 1996 Oct

PMID : 8896890






2 Functional Relationships(s)
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1 Coumarin hydroxylase activity of CYP 2A6 was assessed by administering a probe drug, coumarin, and measuring its metabolite, 7-hydroxycoumarin, in urines collected between 0-2 h and 2-4 h of 106 people with varying intensities of Opisthorchis viverrini infection. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens
2 Reassessments of coumarin hydroxylase activity of CYP 2A6 made 2 months after praziquantel treatment showed highly significant reductions in the amount of 7-hydroxycoumarin excreted among the infected groups but no difference in the uninfected group. 7-hydroxycoumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens