Title : Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1 and identification of insulin receptor substrate-2.

Pub. Date : 1996 Sep

PMID : 8894493






1 Functional Relationships(s)
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1 Moreover, we identified tyrosine phosphorylation of a 190-kDa protein (pp 190) as a novel substrate (IRS-2) for insulin receptor kinase in livers of IRS-1 deficient mice which can bind both P13-kinase and Ash/Grb2. Tyrosine growth factor receptor bound protein 2 Mus musculus