Pub. Date : 1996 Sep
PMID : 8876671
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | Protection against malignant conversion in SENCAR mouse skin by all trans retinoic acid: inhibition of the ras p21-processing enzyme farnesyltransferase and Ha-ras p21 membrane localization. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | In this study, we assessed whether the protective effect of RA against malignant conversion involves the inhibition of ras p21 processing in those tumors that contain the activated ras oncogene. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 4 | Furthermore, the tissue samples from RA-treated groups in different protocols also showed significantly diminished membrane localization of Ha-ras p21, with a concomitant increase in cytosolic Ha-ras p21 levels. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 5 | Furthermore, the tissue samples from RA-treated groups in different protocols also showed significantly diminished membrane localization of Ha-ras p21, with a concomitant increase in cytosolic Ha-ras p21 levels. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 6 | Taken together, these results indicate a strong correlation between the inhibition of ras p21 farnesylation because of a decrease in FTase activity by RA and its protective effect against malignant conversion of papillomas to carcinomas. | Tretinoin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |