Title : Different binding and degradation of proinsulin, insulin and insulin-like growth factor-1 (IGF-1) in cultured renal proximal tubular cells. Implications for the prolonged serum half-life of proinsulin.

Pub. Date : 1996 Jul

PMID : 8870820






1 Functional Relationships(s)
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1 Performing equilibrium binding assays with 125I-labelled hormones, severalfold higher binding was found at the apical than at the basolateral cell membrane, with the capacity range IGF-1 > insulin > proinsulin. Iodine-125 insulin-like growth factor I Oryctolagus cuniculus