Pub. Date : 1996 Oct 1
PMID : 8855340
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Urea-inducible Egr-1 transcription in renal inner medullary collecting duct (mIMCD3) cells is mediated by extracellular signal-regulated kinase activation. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | In the renal medullary mIMCD3 cell line, urea (200-400 milliosmolar) activated both ERK1 and ERK2 as determined by in-gel kinase assay and immune-complex kinase assay of epitope-tagged] ERK1 and ERK2. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 3 | In the renal medullary mIMCD3 cell line, urea (200-400 milliosmolar) activated both ERK1 and ERK2 as determined by in-gel kinase assay and immune-complex kinase assay of epitope-tagged] ERK1 and ERK2. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | Urea-inducible Egr-1 transcription was a consequence of ERK activation because the ERK-specific inhibitor, PD98059, abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 5 | Urea-inducible Egr-1 transcription was a consequence of ERK activation because the ERK-specific inhibitor, PD98059, abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 6 | Urea-inducible Egr-1 transcription was a consequence of ERK activation because the ERK-specific inhibitor, PD98059, abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 1 | Mus musculus |
| 7 | Urea-inducible Egr-1 transcription was a consequence of ERK activation because the ERK-specific inhibitor, PD98059, abrogated transcription from the murine Egr-1 promoter in a luciferase reported gene assay. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | mitogen-activated protein kinase 1 | Mus musculus |
| 8 | In addition, activators of protein kinase A, including forskolin and 8-Br-cAMP, which are known to inhibit ERK-mediated events, also inhibited urea-inducible Egr-1 transcription. | Colforsin | mitogen-activated protein kinase 1 | Mus musculus |
| 9 | In addition, activators of protein kinase A, including forskolin and 8-Br-cAMP, which are known to inhibit ERK-mediated events, also inhibited urea-inducible Egr-1 transcription. | 8-Bromo Cyclic Adenosine Monophosphate | mitogen-activated protein kinase 1 | Mus musculus |
| 10 | In addition, activators of protein kinase A, including forskolin and 8-Br-cAMP, which are known to inhibit ERK-mediated events, also inhibited urea-inducible Egr-1 transcription. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 11 | Furthermore, urea-inducible activation of the physiological ERK substrate and transcription factor, Elk-1, was demonstrated through transient cotransfection of a chimeric Elk-1/GAL4 expression plasmid and a GAL4-driven luciferase reporter plasmid. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 12 | Taken together, these data indicate that, in mIMCD3 cells, urea activates ERKs and the ERK substrate, Elk-1, and that ERK inhibition abrogates urea-inducible Egr-1 transcription. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 13 | Taken together, these data indicate that, in mIMCD3 cells, urea activates ERKs and the ERK substrate, Elk-1, and that ERK inhibition abrogates urea-inducible Egr-1 transcription. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 14 | Taken together, these data indicate that, in mIMCD3 cells, urea activates ERKs and the ERK substrate, Elk-1, and that ERK inhibition abrogates urea-inducible Egr-1 transcription. | Urea | mitogen-activated protein kinase 1 | Mus musculus |
| 15 | These data are consistent with a model of urea-inducible renal medullary gene expression wherein sequential activation of ERKs and Elk-1 results in increased transcription of Egr-1 through serum response element/Ets motifs. | Urea | mitogen-activated protein kinase 1 | Mus musculus |