Pub. Date : 1977 Jul 5
PMID : 884108
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockage of protein synthesis in HeLa cells by cycloheximide leads to selective effects on the levels of DNA polymerases alpha, beta, and gamma in the cell. | Cycloheximide | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 2 | The total activity of DNA polymerase alpha remains unchanged after 7 h exposure of cells to cycloheximide but drops to 50% of its original level after 24 h. The level of the beta-polymerase falls rapidly in the cell and is reduced to less than 30% of its initial value by 7 h after treatment of the cells with cycloheximide. | Cycloheximide | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 3 | The total activity of DNA polymerase alpha remains unchanged after 7 h exposure of cells to cycloheximide but drops to 50% of its original level after 24 h. The level of the beta-polymerase falls rapidly in the cell and is reduced to less than 30% of its initial value by 7 h after treatment of the cells with cycloheximide. | Cycloheximide | DNA polymerase alpha 1, catalytic subunit | Homo sapiens |
| 4 | The cycloheximide-treated cells also show the presence of a new form of the alpha-polymerase, designated alpha1, which can be clearly detected as a separate entity in column chromatography. | Cycloheximide | adrenoceptor alpha 1D | Homo sapiens |
| 5 | The level of alpha1 in the nucleus increases during the period that the cells are treated and cycloheximide so that after 24 h it represents almost 50% of the nuclear DNA polymerase activity. | Cycloheximide | adrenoceptor alpha 1D | Homo sapiens |
| 6 | The presence of alpha1 in the cytoplasmic fraction can also be demonstrated in both cycloheximide-treated and normal, growing cells. | Cycloheximide | adrenoceptor alpha 1D | Homo sapiens |