Pub. Date : 1996 May-Jun
PMID : 8797031
15 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mechanism of depletion of O6-methylguanine-DNA methyltransferase activity in rat tissues by O6-Benzyl-2"-deoxyguanosine. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 2 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 3 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 4 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 5 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 6 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 7 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 8 | O6-Benzyl-2"-deoxyguanosine (O6-BzldGuo) was found to be a potent inhibitor of O6-methylguanine-DNA methyltransferase (MGMT) activity in vivo, despite its demonstrated lower activity compared to O6-benzylguanine (O6-BzlGua) for inactivation of MGMT in cell cultures or cell free extracts. | O(6)-benzylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 9 | At doses above 50 mg/kg, O6-BzldGuo completely suppresses the MGMT activity in liver, lung and brain for 12 to 18 hrs following treatment. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 10 | O6-BzldGuo is metabolized mainly in the liver, and possibly in kidney and lung, to yield the more potent MGMT inhibitors O6-BzlGua and O6-Benzyl-7,8-dihydro-8-oxoguanine (O6-Bzl(8-OX)Gua), that reach maximum levels following the decline of the parent compound both in tissues and the circulation. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 11 | O6-BzldGuo is metabolized mainly in the liver, and possibly in kidney and lung, to yield the more potent MGMT inhibitors O6-BzlGua and O6-Benzyl-7,8-dihydro-8-oxoguanine (O6-Bzl(8-OX)Gua), that reach maximum levels following the decline of the parent compound both in tissues and the circulation. | O(6)-benzylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 12 | O6-BzldGuo is metabolized mainly in the liver, and possibly in kidney and lung, to yield the more potent MGMT inhibitors O6-BzlGua and O6-Benzyl-7,8-dihydro-8-oxoguanine (O6-Bzl(8-OX)Gua), that reach maximum levels following the decline of the parent compound both in tissues and the circulation. | O(6)-benzyl-8-oxoguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 13 | O6-BzldGuo is metabolized mainly in the liver, and possibly in kidney and lung, to yield the more potent MGMT inhibitors O6-BzlGua and O6-Benzyl-7,8-dihydro-8-oxoguanine (O6-Bzl(8-OX)Gua), that reach maximum levels following the decline of the parent compound both in tissues and the circulation. | o6-bzl | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 14 | O6-BzldGuo is metabolized mainly in the liver, and possibly in kidney and lung, to yield the more potent MGMT inhibitors O6-BzlGua and O6-Benzyl-7,8-dihydro-8-oxoguanine (O6-Bzl(8-OX)Gua), that reach maximum levels following the decline of the parent compound both in tissues and the circulation. | 8-ox | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 15 | Although O6-BzldGuo may cause the initial drop of MGMT activity, continued prolonged suppression is likely due to the persistence of its MGMT-inhibiting metabolites. | O(6)-benzyl-2'-deoxyguanosine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |