Title : Synthesis and secretion of B-100 and A-I apolipoproteins in response to the changes of intracellular cholesteryl ester content in chick liver.

Pub. Date : 1996 Mar

PMID : 8728313






3 Functional Relationships(s)
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1 We investigated in the chick whether the diet-induced changes of the hepatic content of cholesteryl esters (CE) influence the synthesis and the secretion of apoB- and apoA-I-containing lipoproteins. Cholesterol Esters apolipoprotein AI Gallus gallus
2 In CH-F chicks, the intracellular and medium 35S-labeled apoA-I were 2-fold the values found in controls (SD-1); apoA-I production returned to the control level only after 5 weeks of cholesterol depletion (CH-DD). Sulfur-35 apolipoprotein AI Gallus gallus
3 Thus, in response to hepatic CE accumulation induced by cholesterol feeding, a larger proportion of newly synthesized apoB is driven to the secretory pathway and more apoA-I is synthesized. Cholesterol apolipoprotein AI Gallus gallus