Pub. Date : 1996 Aug 9
PMID : 8702658
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Hsp40 stimulates the hydrolysis of ATP by Hsc70, causing a approximately 7-fold increase in its steady-state ATPase activity. | Adenosine Triphosphate | DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 | Homo sapiens |
| 2 | As a result of its ATPase stimulating activity, addition of Hsp40 allows Hsc70 to bind peptide in the presence of ATP, whereas in the absence of Hsp40, peptide is efficiently released upon ATP binding to Hsc70. | Adenosine Triphosphate | DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 | Homo sapiens |
| 3 | As a result of its ATPase stimulating activity, addition of Hsp40 allows Hsc70 to bind peptide in the presence of ATP, whereas in the absence of Hsp40, peptide is efficiently released upon ATP binding to Hsc70. | Adenosine Triphosphate | DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 | Homo sapiens |
| 4 | The functional cooperation of Hsp40 with Hsc70 is essential to ensure the ATP hydrolysis-dependent binding of aggregation-sensitive denatured polypeptides, such as thermally denatured firefly luciferase and chemically denatured rhodanese. | Adenosine Triphosphate | DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 | Homo sapiens |
| 5 | Hsc70 and Hsp40 cooperate with further factors in protein renaturation, as demonstrated by the finding that luciferase, thermally denatured in the presence of Hsc70, Hsp40, and ATP, refolds upon addition of rabbit reticulocyte cytosol. | Adenosine Triphosphate | DnaJ heat shock protein family (Hsp40) member B1 pseudogene 1 | Homo sapiens |