Title : Enhancement of CPP32-like activity in the TNF-treated U937 cells by the proteasome inhibitors.

Pub. Date : 1996 Jul 5

PMID : 8694836






3 Functional Relationships(s)
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1 Unexpectedly, proteasome inhibitors (at 5 microM) such as Z-LLnV, Z-LLL, and lactacystin enhanced CPP32-like activity, Ac-DEVD-MCA degrading activity, in the TNF-treated U937 cells in 3 hr, but E64d, cysteine protease inhibitor, did not. benzyloxycarbonylleucyl-leucyl-leucine aldehyde caspase 3 Homo sapiens
2 Unexpectedly, proteasome inhibitors (at 5 microM) such as Z-LLnV, Z-LLL, and lactacystin enhanced CPP32-like activity, Ac-DEVD-MCA degrading activity, in the TNF-treated U937 cells in 3 hr, but E64d, cysteine protease inhibitor, did not. benzyloxycarbonylleucyl-leucyl-leucine aldehyde tumor necrosis factor Homo sapiens
3 Unexpectedly, proteasome inhibitors (at 5 microM) such as Z-LLnV, Z-LLL, and lactacystin enhanced CPP32-like activity, Ac-DEVD-MCA degrading activity, in the TNF-treated U937 cells in 3 hr, but E64d, cysteine protease inhibitor, did not. benzyloxycarbonylleucyl-leucyl-leucine aldehyde cathepsin B Homo sapiens