Title : Pharmacokinetics of O6-benzylguanine in rats and its metabolism by rat liver microsomes.

Pub. Date : 1995 Dec

PMID : 8689950






1 Functional Relationships(s)
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1 O6-Benzylguanine is an effective inhibitor of the DNA repair protein, O6-alkylguanine-DNA alkyltransferase, and enhances the effectiveness of 1,3-bis(2-chloroethyl)-1-nitrosourea in cells in culture and animal tumor models. O(6)-benzylguanine O-6-methylguanine-DNA methyltransferase Rattus norvegicus