Title : Neoplastic transformation induced by insulin receptor substrate-1 overexpression requires an interaction with both Grb2 and Syp signaling molecules.

Pub. Date : 1996 Jun 14

PMID : 8662827






2 Functional Relationships(s)
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1 Mutations of tyrosine 897 in the YVNI motif (Y897F) and of tyrosine 1180 in the YIDL motif (Y1180F) reduced the intracellular interaction of IRS-1 with Grb2 and Syp proteins, respectively. Tyrosine growth factor receptor bound protein 2 Mus musculus
2 Mutations of tyrosine 897 in the YVNI motif (Y897F) and of tyrosine 1180 in the YIDL motif (Y1180F) reduced the intracellular interaction of IRS-1 with Grb2 and Syp proteins, respectively. Tyrosine growth factor receptor bound protein 2 Mus musculus