Title : Guanine, pyrazolo[3,4-d]pyrimidine, and triazolo[4,5-d]pyrimidine (8-azaguanine) phosphonate acyclic derivatives as inhibitors of purine nucleoside phosphorylase.

Pub. Date : 1996 Feb 16

PMID : 8632418






4 Functional Relationships(s)
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1 Phosphonate acyclic derivates of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki" values ranging from 0.05 to 1.6 microM. Organophosphonates polyribonucleotide nucleotidyltransferase 1 Homo sapiens
2 Phosphonate acyclic derivates of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki" values ranging from 0.05 to 1.6 microM. pyrazolo(3,4-d)pyrimidine polyribonucleotide nucleotidyltransferase 1 Homo sapiens
3 Phosphonate acyclic derivates of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki" values ranging from 0.05 to 1.6 microM. Azaguanine polyribonucleotide nucleotidyltransferase 1 Homo sapiens
4 These compounds are enzymatically stable congeners of the potent PNPase inhibitor acyclovir diphosphate (53). Acyclovir Diphosphate polyribonucleotide nucleotidyltransferase 1 Homo sapiens