Title : Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac.

Pub. Date : 1995 Dec

PMID : 8605291






6 Functional Relationships(s)
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Protein Name
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1 Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus
2 Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus
3 We report here that we have identified the 110 kDa diclofenac-labeled protein in rat liver as dipeptidyl peptidase IV, also known as CD26. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus
4 We report here that we have identified the 110 kDa diclofenac-labeled protein in rat liver as dipeptidyl peptidase IV, also known as CD26. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus
5 In addition, we found that the activity of dipeptidyl peptidase IV in liver plasma membrane fractions was lowered after diclofenac treatment of rats. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus
6 These results suggest that the hepatotoxicity associated with diclofenac might be due, in part, to the covalent modification of dipeptidyl peptidase IV. Diclofenac dipeptidylpeptidase 4 Rattus norvegicus