Title : The effect of thalidomide on the pathogenesis of human immunodeficiency virus type 1 and M. tuberculosis infection.

Pub. Date : 1996 Mar 1

PMID : 8603261






3 Functional Relationships(s)
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1 Thalidomide inhibits the synthesis of TNF-alpha both in vitro and in vivo and may have clinical usefulness. Thalidomide tumor necrosis factor Homo sapiens
2 In patients with concomitant HIV-1 and tuberculosis infections, thalidomide therapy was associated with a reduction in both plasma TNF-alpha levels and HIV-1 levels. Thalidomide tumor necrosis factor Homo sapiens
3 The results of this pilot study suggest that thalidomide may have a clinical role in enhancing weight gain and possibly reducing TNF-alpha and HIV-1 levels in patients with HIV-1 and concomitant mycobacterial infections. Thalidomide tumor necrosis factor Homo sapiens