Title : Glucocorticoid-mediated gene suppression of rat cytokine-induced neutrophil chemoattractant CINC/gro, a member of the interleukin-8 family, through impairment of NF-kappa B activation.

Pub. Date : 1996 Jan 19

PMID : 8576166






4 Functional Relationships(s)
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1 The glucocorticoid dexamethasone inhibited the production of the rat cytokine-induced neutrophil chemoattractant CINC/gro, a counterpart of human melanoma growth-stimulating activity that belongs to the interleukin-8 (IL-8) family, in the normal rat kidney epithelial cell line NRK-52E stimulated with interleukin-1 beta (IL-1 beta), lipopolysaccharide, or tumor necrosis factor alpha. Dexamethasone C-X-C motif chemokine ligand 1 Rattus norvegicus
2 The accumulation of CINC/gro mRNA induced by these activators was also decreased comparably by dexamethasone. Dexamethasone C-X-C motif chemokine ligand 1 Rattus norvegicus
3 A nuclear run-on assay revealed that dexamethasone decreased the IL-1 beta-induced transcription of the CINC/gro gene. Dexamethasone C-X-C motif chemokine ligand 1 Rattus norvegicus
4 Furthermore, a tandem repeat of the NF-kappa B sequence in the CINC/gro gene conferred the inducibility by IL-1 beta and suppression of luciferase activity by dexamethasone. Dexamethasone C-X-C motif chemokine ligand 1 Rattus norvegicus