Title : A combined kinetic and modeling study of the catalytic center subsites of human angiogenin.

Pub. Date : 1996 Jan 23

PMID : 8570639






1 Functional Relationships(s)
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1 Although the B2 site that preferentially binds purines on the 3" side of B1 is also weak, its associated phosphate subsites make substantial contributions: both 3",5"-ADP and 5"-ADP have Ki values 6-fold lower than for 5"-AMP, and adding a 3"-phosphate to the substrate CpA increases Kcat/Km by 9-fold. adenosine 5'-O-(2-thiodiphosphate) carboxypeptidase A1 Homo sapiens