Title : Specific involvement of tyrosine 764 of human granulocyte colony-stimulating factor receptor in signal transduction mediated by p145/Shc/GRB2 or p90/GRB2 complexes.

Pub. Date : 1996 Jan 1

PMID : 8547634






3 Functional Relationships(s)
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Protein Name
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1 G-CSF induced formation of Syp/GRB2 complexes in all the tyrosine-substitution mutants, suggesting that this association did not depend on the presence of single specific tyrosine residues in G-CSF-R. Tyrosine growth factor receptor bound protein 2 Mus musculus
2 In contrast, tyrosine 764 of G-CSF-R appeared to be exclusively required for tyrosine phosphorylation of Shc and its association with p145 and GRB2. Tyrosine growth factor receptor bound protein 2 Mus musculus
3 In addition, tyrosine 764 also specifically mediated binding of GRB2 to p90 without the involvement of Shc. Tyrosine growth factor receptor bound protein 2 Mus musculus