Title : The SH2 domain of Shc suppresses EGF-induced mitogenesis in a dominant negative manner.

Pub. Date : 1995 Dec 21

PMID : 8545109






1 Functional Relationships(s)
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1 In this report, we have shown that in these cells, in response to EGF, Ras is fully activated with formation of the tyrosine-phosphorylated Shc-Grb2-mSOS complex without the receptor. Tyrosine growth factor receptor bound protein 2 Mus musculus