Title : Low oxygen enhances sickle and normal erythropoiesis and fetal hemoglobin synthesis in vitro.

Pub. Date : 1995 Sep

PMID : 8537230






6 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Relative synthesis of gamma-globin was examined by labeling with 3H-leucine and electrophoresis on Triton acid urea polyacrylamide gels. DL-Leucine hemoglobin subunit gamma 1 Homo sapiens
2 Relative synthesis of gamma-globin was examined by labeling with 3H-leucine and electrophoresis on Triton acid urea polyacrylamide gels. triton acid urea hemoglobin subunit gamma 1 Homo sapiens
3 Relative synthesis of gamma-globin was examined by labeling with 3H-leucine and electrophoresis on Triton acid urea polyacrylamide gels. polyacrylamide hemoglobin subunit gamma 1 Homo sapiens
4 In sickle cultures, hemin and low oxygen had additive effects on colony growth, but only low oxygen increased gamma-globin synthesis. Oxygen hemoglobin subunit gamma 1 Homo sapiens
5 Interleukin-3 also increased gamma-globin synthesis in low oxygen in normal but not sickle cultures. Oxygen hemoglobin subunit gamma 1 Homo sapiens
6 Thus, low oxygen increases in vitro sensitivity to erythropoietin, colony numbers, and relative gamma-globin synthesis in normal and sickle cultures. Oxygen hemoglobin subunit gamma 1 Homo sapiens