Title : Stimulation of insulin secretion and improvement of glucose tolerance in rat and dog by the P2y-purinoceptor agonist, adenosine-5'-O-(2-thiodiphosphate).

Pub. Date : 1993 May

PMID : 8495239






3 Functional Relationships(s)
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1 administered ADP beta S (0.2 mg kg-1) produced an insulin response dependent on the nutritional state of the animals, since we observed only a transient increase in overnight-fasted rats and a sustained insulin secretion followed by a reduction in plasma glucose levels in fed rats. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
2 glucose tolerance test, ADP beta S enhanced insulin release and thus increased the glucose disappearance rate. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
3 In conclusion, the P2y-agonist, ADP beta S, is a potent insulin secretagogue in vivo, improves glucose tolerance and is effective after oral administration. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris