Title : Thymic T cell anergy in autoimmune nonobese diabetic mice is mediated by deficient T cell receptor regulation of the pathway of p21ras activation.

Pub. Date : 1993 Apr 1

PMID : 8459217






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Activation of p21ras is deficient in quiescent and stimulated NOD T cells, and this is correlated with a significant reduction in the tyrosine phosphorylation of p42mapk, a serine/threonine kinase active downstream of p21ras. Tyrosine mitogen-activated protein kinase 1 Mus musculus
2 Treatment of NOD T cells with a phorbol ester not only enhances their p21ras activity and p42mapk tyrosine phosphorylation but also restores their proliferative responsiveness. Phorbol Esters mitogen-activated protein kinase 1 Mus musculus
3 Treatment of NOD T cells with a phorbol ester not only enhances their p21ras activity and p42mapk tyrosine phosphorylation but also restores their proliferative responsiveness. Tyrosine mitogen-activated protein kinase 1 Mus musculus
4 Since p42mapk activity is required for progression through to S phase of the cell cycle, our data suggest that reduced tyrosine phosphorylation of p42mapk in stimulated NOD T cells may abrogate its activity and elicit the proliferative unresponsiveness of these cells. Tyrosine mitogen-activated protein kinase 1 Mus musculus