Title : Direct demonstration that the A gamma T globin gene is linked to the 4 bp promoter deletion in the beta A chromosome of sickle cell traits.

Pub. Date : 1993 Aug

PMID : 8372815






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In beta zero-thalassemia and sickle cell patients, a 4 bp deletion at -222 to -225 of the A gamma globin promoter was associated with low expression of the A gamma T variant (threonine at codon 75 of A gamma), whereas A gamma I (isoleucine at 75) had the normal A gamma promoter and higher expression. Threonine hemoglobin subunit gamma 1 Homo sapiens
2 In beta zero-thalassemia and sickle cell patients, a 4 bp deletion at -222 to -225 of the A gamma globin promoter was associated with low expression of the A gamma T variant (threonine at codon 75 of A gamma), whereas A gamma I (isoleucine at 75) had the normal A gamma promoter and higher expression. Isoleucine hemoglobin subunit gamma 1 Homo sapiens