Title : Clusterin, the human apolipoprotein and complement inhibitor, binds to complement C7, C8 beta, and the b domain of C9.

Pub. Date : 1993 Aug 15

PMID : 8345200






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Together with vitronectin, clusterin binds to the nascent amphiphilic C5b-9 complex, rendering it water soluble and lytically inactive. Water clusterin Homo sapiens
2 By using ligand blotting in the presence of Tween, specific binding of the labeled clusterin with C7, the beta-subunit of C8 and C9 was detected. Polysorbates clusterin Homo sapiens
3 Both subunits of clusterin interact with C9 and are similarly potent in inhibiting C5b-9-mediated hemolysis and Zn+(+)-induced C9 polymerization. Zinc clusterin Homo sapiens