Title : A double-blind controlled trial of oral-pulse methotrexate therapy in the treatment of primary sclerosing cholangitis.

Pub. Date : 1994 Feb

PMID : 8299916






6 Functional Relationships(s)
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1 Because methotrexate was associated with clinical and histological improvement in two men with PSC, we conducted a prospective trial of methotrexate in PSC. Methotrexate PSC Homo sapiens
2 Because methotrexate was associated with clinical and histological improvement in two men with PSC, we conducted a prospective trial of methotrexate in PSC. Methotrexate PSC Homo sapiens
3 METHODS: A prospective placebo-controlled, double-blind trial of methotrexate in PSC was performed. Methotrexate PSC Homo sapiens
4 Twenty-four patients with PSC were randomized to receive methotrexate or placebo for a 2-year period. Methotrexate PSC Homo sapiens
5 On the basis of this study, the empiric use of methotrexate in patients with PSC is not recommended. Methotrexate PSC Homo sapiens
6 However, methotrexate is being further evaluated in patients with precirrhotic PSC. Methotrexate PSC Homo sapiens