Title : Antisense inhibition of the p65 subunit of NF-kappa B blocks tumorigenicity and causes tumor regression.

Pub. Date : 1993 Nov 1

PMID : 8234333






3 Functional Relationships(s)
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1 In diverse transformed cell lines, phosphorothioate antisense oligonucleotides to p65 inhibited in vitro growth, reduced soft-agar colony formation, and eliminated the ability of cells to adhere to an extracellular matrix. Parathion v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
2 In diverse transformed cell lines, phosphorothioate antisense oligonucleotides to p65 inhibited in vitro growth, reduced soft-agar colony formation, and eliminated the ability of cells to adhere to an extracellular matrix. Oligonucleotides v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus
3 Stable transfectants of a fibrosarcoma cell line expressing dexamethasone-inducible antisense RNA to p65 showed inhibition of in vitro growth and in vivo tumor development. Dexamethasone v-rel reticuloendotheliosis viral oncogene homolog A (avian) Mus musculus