Title : ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

Pub. Date : 1993 Nov 25

PMID : 8227009






4 Functional Relationships(s)
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1 ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. lysophosphatidic acid cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
2 ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. Tyrosine cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
3 Pretreatment of the cells with the C3 exoenzyme caused ADP-ribosylation of rho p21 in the cells and selectively attenuated the phosphorylation of several proteins, including p43 mitogen-activated protein kinase, p125 focal adhesion kinase, and two proteins of 72 and 88 kDa. Adenosine Diphosphate cyclin-dependent kinase inhibitor 1A (P21) Mus musculus
4 These findings suggest that rho p21 works as a link between the LPA receptor signal and the subsequent tyrosine phosphorylation and PI 3-kinase activation in these cells. Tyrosine cyclin-dependent kinase inhibitor 1A (P21) Mus musculus