Title : Role of glycosylation in the biosynthesis and activity of rabbit testicular angiotensin-converting enzyme.

Pub. Date : 1994 May 24

PMID : 8193137






5 Functional Relationships(s)
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1 In the present study, we investigated the role of N- and O-glycosylation in intracellular transport and extracellular cleavage-secretion of rabbit testicular ACE. Nitrogen angiotensin-converting enzyme Oryctolagus cuniculus
2 Our experiments demonstrated that newly synthesized ACE acquires both N- and O-linked sugars before its cleavage-secretion and complete blockage of glycosylation results in rapid intracellular turnover of underglycosylated ACE. n- and o-linked sugars angiotensin-converting enzyme Oryctolagus cuniculus
3 However, ACE synthesized without N-linked complex sugars and O-linked sugars can undergo normal transport and cleavage-secretion, and the underglycosylated protein is enzymatically active. Nitrogen angiotensin-converting enzyme Oryctolagus cuniculus
4 However, ACE synthesized without N-linked complex sugars and O-linked sugars can undergo normal transport and cleavage-secretion, and the underglycosylated protein is enzymatically active. Sugars angiotensin-converting enzyme Oryctolagus cuniculus
5 However, ACE synthesized without N-linked complex sugars and O-linked sugars can undergo normal transport and cleavage-secretion, and the underglycosylated protein is enzymatically active. o-linked sugars angiotensin-converting enzyme Oryctolagus cuniculus