Title : Synergistic increases in rat hepatic cytochrome P450s by ethanol and isopentanol.

Pub. Date : 1994 May

PMID : 8182553






7 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The purpose of this study was to determine if isopentanol alone or in combination with ethanol increased CYP2B1/2, CYP2E or CYP3A in the livers of rats. isopentyl alcohol cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus
2 The purpose of this study was to determine if isopentanol alone or in combination with ethanol increased CYP2B1/2, CYP2E or CYP3A in the livers of rats. isopentyl alcohol cytochrome P450, family 2, subfamily e, polypeptide 1 Rattus norvegicus
3 The purpose of this study was to determine if isopentanol alone or in combination with ethanol increased CYP2B1/2, CYP2E or CYP3A in the livers of rats. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
4 Isopentanol alone caused small increases in CYP2B1/2 and CYP3A. isopentyl alcohol cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus
5 Isopentanol alone caused small increases in CYP2B1/2 and CYP3A. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
6 These results confirm our previous findings in cultured hepatocytes that when isopentanol is combined with ethanol, there is a synergistic increase in CYP2B1/2. isopentyl alcohol cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus
7 Increases in CYP2B1/2, CYP2E and CYP3A protein moieties by ethanol, and by ethanol in combination with isopentanol, were associated with increases in their mRNAs. isopentyl alcohol cytochrome P450, family 2, subfamily b, polypeptide 1 Rattus norvegicus