Title : Relationship of calcium transients to calcium currents and charge movements in myotubes expressing skeletal and cardiac dihydropyridine receptors.

Pub. Date : 1994 Jan

PMID : 8169595






7 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In cardiac muscle the DHP receptor functions as a rapidly-activated calcium channel and the influx of calcium through this channel induces calcium release from the sarcoplasmic reticulum (SR). Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
2 In cardiac muscle the DHP receptor functions as a rapidly-activated calcium channel and the influx of calcium through this channel induces calcium release from the sarcoplasmic reticulum (SR). Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
3 In contrast, in skeletal muscle the DHP receptor functions as a voltage sensor and as a slowly-activating calcium channel; in this case, the voltage sensor controls SR calcium release. Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
4 It has been previously demonstrated that injection of dysgenic myotubes with cDNA (pCAC6) encoding the skeletal muscle DHP receptor restores the slow calcium current and skeletal type e-c coupling that does not require entry of external calcium (Tanabe, Beam, Powell, and Numa. Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
5 It has been previously demonstrated that injection of dysgenic myotubes with cDNA (pCAC6) encoding the skeletal muscle DHP receptor restores the slow calcium current and skeletal type e-c coupling that does not require entry of external calcium (Tanabe, Beam, Powell, and Numa. Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
6 Furthermore, injection of cDNA (pCARD1) encoding the cardiac DHP receptor produces rapidly activating calcium current and cardiac type e-c coupling that does require calcium entry (Tanabe, Mikami, Numa, and Beam. Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens
7 Furthermore, injection of cDNA (pCARD1) encoding the cardiac DHP receptor produces rapidly activating calcium current and cardiac type e-c coupling that does require calcium entry (Tanabe, Mikami, Numa, and Beam. Calcium calcium voltage-gated channel subunit alpha1 S Homo sapiens