Pub. Date : 1994 Mar
PMID : 8118929
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparison of O6-methylguanine-DNA methyltransferase mRNA levels in Ha-ras mutated and non-mutated rat mammary tumors induced by N-methyl-N-nitrosourea. | Methylnitrosourea | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 2 | However, a DNA repair enzyme, O6-methylguanine-DNA methyltransferase (MGMT), can specifically remove methyl groups from O6-methylguanine, which is a major mutagenic and carcinogenic DNA lesion leading to the G-->A transition. | O-(6)-methylguanine | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |
| 3 | In this study, we compared the amount of MGMT mRNA in MNU-induced rat mammary tumors with and without such Ha-ras activation. | Methylnitrosourea | O-6-methylguanine-DNA methyltransferase | Rattus norvegicus |