Pub. Date : 1994 Dec 22-29
PMID : 7997267
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The GRB2 SH2 domain binds directly to tyrosine-phosphorylated FAK. | Tyrosine | growth factor receptor bound protein 2 | Mus musculus |
| 2 | Mutation of tyrosine residue 925 of FAK (YENV motif) to phenylalanine blocks GRB2 SH2-domain binding to FAK in vitro. | Tyrosine | growth factor receptor bound protein 2 | Mus musculus |
| 3 | Mutation of tyrosine residue 925 of FAK (YENV motif) to phenylalanine blocks GRB2 SH2-domain binding to FAK in vitro. | Phenylalanine | growth factor receptor bound protein 2 | Mus musculus |
| 4 | Phosphorylation of FAK at Tyr 925 upon fibronectin stimulation creates an SH2-binding site for GRB2 which may link integrin engagement to the activation of the Ras/MAPK signal transduction pathway. | Tyrosine | growth factor receptor bound protein 2 | Mus musculus |