Title : The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts.

Pub. Date : 1994 Jul

PMID : 7945993






2 Functional Relationships(s)
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1 Desipramine induced rapid intracellular degradation of mature acid sphingomyelinase when added to the cells in the micromolar range, concomitantly abolishing the enzyme activity. Desipramine sphingomyelin phosphodiesterase 1 Homo sapiens
2 From these results we conclude that desipramine and possibly also similarly acting tricyclic antidepressants induce proteolytic degradation of acid sphingomyelinase. Desipramine sphingomyelin phosphodiesterase 1 Homo sapiens