Pub. Date : 1994 Oct 14
PMID : 7932578
10 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The preparation and in vitro prolyl endopeptidase (PEP) inhibitory activity of a series of alpha-keto heterocyclic compounds is described. | alpha-keto heterocyclic compounds | prolyl endopeptidase | Homo sapiens |
| 2 | The preparation and in vitro prolyl endopeptidase (PEP) inhibitory activity of a series of alpha-keto heterocyclic compounds is described. | alpha-keto heterocyclic compounds | prolyl endopeptidase | Homo sapiens |
| 3 | Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels. | Thiazoles | prolyl endopeptidase | Homo sapiens |
| 4 | Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels. | benzothiazole | prolyl endopeptidase | Homo sapiens |
| 5 | Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels. | Benzoxazoles | prolyl endopeptidase | Homo sapiens |
| 6 | Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels. | imidazole | prolyl endopeptidase | Homo sapiens |
| 7 | Many of the compounds including those substituted with thiazole, benzothiazole, benzoxazole, imidazole, and pyridine groups exhibit IC50 potencies of PEP inhibition at nanomolar levels. | pyridine | prolyl endopeptidase | Homo sapiens |
| 8 | This heterocyclic nitrogen atom would provide a critical hydrogen-bond interaction with the histidine residue of the catalytic triad in PEP. | Nitrogen | prolyl endopeptidase | Homo sapiens |
| 9 | This heterocyclic nitrogen atom would provide a critical hydrogen-bond interaction with the histidine residue of the catalytic triad in PEP. | Hydrogen | prolyl endopeptidase | Homo sapiens |
| 10 | This heterocyclic nitrogen atom would provide a critical hydrogen-bond interaction with the histidine residue of the catalytic triad in PEP. | Histidine | prolyl endopeptidase | Homo sapiens |