Title : Acute ethanol exposure suppresses the repair of O6-methylguanine DNA lesions in castrated adult male rats.

Pub. Date : 1994 Oct

PMID : 7847618






5 Functional Relationships(s)
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1 Toward this end, we report the inhibition of O6-methylguanine-DNA methyltransferase (MGMT) by a single intraperitoneal injection of 30% ethanol in adult male castrated rats. Ethanol O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 Toward this end, we report the inhibition of O6-methylguanine-DNA methyltransferase (MGMT) by a single intraperitoneal injection of 30% ethanol in adult male castrated rats. Ethanol O-6-methylguanine-DNA methyltransferase Rattus norvegicus
3 We also observed a dose-response effect of ethanol on MGMT activity, again only in the castrated rats. Ethanol O-6-methylguanine-DNA methyltransferase Rattus norvegicus
4 The finding of ethanol"s effect on MGMT activity in castrated and not intact rats implies a hormonal component of MGMT DNA repair response, which has only been alluded to in past research. Ethanol O-6-methylguanine-DNA methyltransferase Rattus norvegicus
5 The finding of ethanol"s effect on MGMT activity in castrated and not intact rats implies a hormonal component of MGMT DNA repair response, which has only been alluded to in past research. Ethanol O-6-methylguanine-DNA methyltransferase Rattus norvegicus