Pub. Date : 1995 Jan 17
PMID : 7819246
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | On the basis of Km, kcat and kcat/Km values, (Ser21)PKI alpha(14-22) amide (numbering based upon native PKI alpha) is the most effective peptide substrate yet discovered for either kinase, although other peptides, while phosphorylated considerably less efficiently by PKG, are more specific. | Amides | protein kinase cGMP-dependent 1 | Homo sapiens |
| 2 | Although the inhibitory peptide corresponding to this sequence (i.e., with an Ala at position 21) is a much more potent inhibitor of PKA than of PKG (approximately 250-fold), PKG actually exhibits a 60% higher kcat than does PKA with the (Ser21)PKI alpha(14-22) amide substrate peptide, with only a 20-fold higher Km value. | Alanine | protein kinase cGMP-dependent 1 | Homo sapiens |
| 3 | Although the inhibitory peptide corresponding to this sequence (i.e., with an Ala at position 21) is a much more potent inhibitor of PKA than of PKG (approximately 250-fold), PKG actually exhibits a 60% higher kcat than does PKA with the (Ser21)PKI alpha(14-22) amide substrate peptide, with only a 20-fold higher Km value. | Amides | protein kinase cGMP-dependent 1 | Homo sapiens |