Pub. Date : 1995 Jan
PMID : 7815356
12 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 5-Aminosalicylic acid abrogates T-cell proliferation by blocking interleukin-2 production in peripheral blood mononuclear cells. | Mesalamine | interleukin 2 | Homo sapiens |
| 2 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 3 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 4 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 5 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 6 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 7 | We tested whether SS or its metabolites 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP) inhibited the T-cell activation products interleukin 2 (IL-2) and interleukin 2 receptor alpha-chain (IL-2R alpha). | Mesalamine | interleukin 2 | Homo sapiens |
| 8 | 5-ASA (625 microM) markedly reduced culture supernatant IL-2 protein levels by 92% and steady-state IL-2 messenger RNA levels 4.4-fold at 24 and 18 hr, respectively. | Mesalamine | interleukin 2 | Homo sapiens |
| 9 | 5-ASA (625 microM) markedly reduced culture supernatant IL-2 protein levels by 92% and steady-state IL-2 messenger RNA levels 4.4-fold at 24 and 18 hr, respectively. | Mesalamine | interleukin 2 | Homo sapiens |
| 10 | The supplementation of IL-2 restored T-cell proliferation only in 5-ASA-treated cultures. | Mesalamine | interleukin 2 | Homo sapiens |
| 11 | 5-ASA inhibits T-cell proliferation in part by blocking IL-2 messenger RNA accumulation and protein production downstream of the rise in cytosolic calcium. | Mesalamine | interleukin 2 | Homo sapiens |
| 12 | Inhibition of IL-2 production is an additional mechanism of action for 5-ASA. | Mesalamine | interleukin 2 | Homo sapiens |