Title : In vivo and in vitro effects of adenosine-5'-O-(2-thiodiphosphate) on pancreatic hormones in dogs.

Pub. Date : 1994 Sep

PMID : 7809020






6 Functional Relationships(s)
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1 Adenosine-5"-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
2 Adenosine-5"-O-(2-thiodiphosphate) (ADP beta S), a P2y purinergic agonist, has been shown to be a potent insulin secretagogue on the isolated rat pancreas. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
3 In the present work the effects of ADP beta S on insulin somatostatin, and glucagon secretions were investigated in dogs. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
4 ADP beta S (0.1 mg kg-1) produced an immediate and transient augmentation in plasma insulin levels but not in plasma SLI and glucagon levels. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
5 In normal uncinate process, in presence of 8.3 mM glucose, ADP beta S (1 microM) stimulated insulin and SLI releases but not glucagon release. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris
6 In conclusion, ADP beta S is a potent insulin secretory agent in dog. adenosine 5'-O-(2-thiodiphosphate) insulin Canis lupus familiaris