Title : Inhibition of bone resorption in vitro by selective inhibitors of gelatinase and collagenase.

Pub. Date : 1995 May 15

PMID : 7755562






1 Functional Relationships(s)
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1 Both compounds dose-dependently inhibited 1,25-dihydroxyvitamin D3 (10(-8) M)-stimulated degradation of type-I collagen by mouse calvarial osteoblasts; however, complete inhibition of collagenolysis was only achieved at concentrations at which CT1166 and Ro 31-7467 act as general MMP inhibitors. Calcitriol matrix metallopeptidase 2 Mus musculus