Pub. Date : 1995 May 4
PMID : 7729953
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 2 | Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 3 | A clear induction of WAF1/CIP1 and GADD45 genes in cells expressing wild-type p53 after Doxorubicin treatment was found. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 4 | A clear induction of WAF1/CIP1 and GADD45 genes in cells expressing wild-type p53 after Doxorubicin treatment was found. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 5 | Doxorubicin was also able to induce the transcription of WAF1/CIP1 gene in SKN cells (not expressing p53) or in SK23a cells at 37 degrees C (expressing mutated p53), indicating that the expression of this gene also, in some tumor-cell lines, is not necessarily or uniquely induced by wild-type p53. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |
| 6 | Doxorubicin was also able to induce the transcription of WAF1/CIP1 gene in SKN cells (not expressing p53) or in SK23a cells at 37 degrees C (expressing mutated p53), indicating that the expression of this gene also, in some tumor-cell lines, is not necessarily or uniquely induced by wild-type p53. | Doxorubicin | cyclin dependent kinase inhibitor 1A | Homo sapiens |