Pub. Date : 1995 Apr
PMID : 7727042
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of ras p21 membrane localization and modulation of protein kinase C isozyme expression during regression of chemical carcinogen-induced murine skin tumors by lovastatin. | Lovastatin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | However, when ras p21 membrane localization was blocked in vivo in growing tumors by lovastatin, opposite results were evident. | Lovastatin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | Compared with saline-treated animals, in which tumor growth continued, lovastatin-treated animals had significantly inhibited tumor growth, which led to tumor regression with concomitant inhibition of Ha-ras p21 membrane localization. | Lovastatin | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |