Title : Induction of rat liver drug-metabolizing enzymes by tetrachloroethylene.

Pub. Date : 1995 Apr

PMID : 7726643






1 Functional Relationships(s)
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1 In addition to cytochrome P450-mediated monooxygenases, there was significant induction of the Phase II drug-metabolizing enzymes, DT-diaphorase, glutathione S-transferase activities towards 1-chloro-2,4-dinitrobenzene and 1,2-dichloro-4-nitrobenzene, and UDP-glucuronyltransferase activities towards 4-nitrophenol and 7-hydroxycoumarin. 7-hydroxycoumarin hematopoietic prostaglandin D synthase Rattus norvegicus