Pub. Date : 1995 Feb
PMID : 7662118
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ha-ras p21-GTP levels remain constant during primary keratinocyte differentiation. | Guanosine Triphosphate | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 2 | In the present studies, we measured the level and activity state of Ha-ras p21 protein in cultured keratinocytes undergoing calcium-induced differentiation. | Calcium | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 3 | The percentage of Ha-ras p21 protein in its active, GTP-bound form also remained unchanged during primary adult keratinocyte differentiation and in immortalized, benign, and malignant keratinocytes subjected to differentiating conditions. | Guanosine Triphosphate | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |
| 4 | Our results indicate that terminal differentiation of primary adult mouse keratinocytes occurred in the presence of constant levels of Ha-ras p21-GTP, suggesting that the Ha-ras signaling pathway may be blocked at a point distal to a step involving the Ha-ras p21 protein itself. | Guanosine Triphosphate | cyclin-dependent kinase inhibitor 1A (P21) | Mus musculus |