Title : Transforming growth factor beta 1-hyaluronic acid interaction.

Pub. Date : 1995 Aug

PMID : 7648625






7 Functional Relationships(s)
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1 Transforming growth factor beta 1-hyaluronic acid interaction. Hyaluronic Acid transforming growth factor beta 1 Gallus gallus
2 Chick embryo skin fibroblasts release transforming growth factor beta 1 that is able to modulate glycosaminoglycan synthesis and secretion. Glycosaminoglycans transforming growth factor beta 1 Gallus gallus
3 Untreated transforming growth factor beta 1 suppressed the proliferative response of thymocytes to interleukin-1, as did transforming growth factor beta 1 pre-incubated with sulphated glycosaminoglycans. sulphated glycosaminoglycans transforming growth factor beta 1 Gallus gallus
4 By contrast, transforming growth factor beta 1 lost its inhibitory capacity when preincubated with high molecular weight hyaluronic acid. Hyaluronic Acid transforming growth factor beta 1 Gallus gallus
5 Digestion of transforming growth factor beta 1-hyaluronic acid complex with hyaluronidase released active transforming growth factor beta 1. Hyaluronic Acid transforming growth factor beta 1 Gallus gallus
6 Digestion of transforming growth factor beta 1-hyaluronic acid complex with hyaluronidase released active transforming growth factor beta 1. Hyaluronic Acid transforming growth factor beta 1 Gallus gallus
7 These results suggest that hyaluronic acid interacts with transforming growth factor beta 1, thus protecting the factor from tryptic degradation and may be a means of concentrating growth factor activity. Hyaluronic Acid transforming growth factor beta 1 Gallus gallus